GlutaredoxinV1, Main, Exploration, bibRecord, 000871

Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease.

Identifieur interne : 000871 ( Main/Exploration ); précédent : 000870; suivant : 000872

Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease.

Auteurs : Sidra M. Hoffman [États-Unis] ; Jane E. Tully ; Karolyn G. Lahue ; Vikas Anathy ; James D. Nolin ; Amy S. Guala ; Jos L J. Van Der Velden ; Ye-Shih Ho ; Minara Aliyeva ; Nirav Daphtary ; Lennart K A. Lundblad ; Charles G. Irvin ; Yvonne M W. Janssen-Heininger

Source :

American journal of physiology. Lung cellular and molecular physiology [ 1522-1504 ] ; 2012.

RBID : pubmed:22752969

Descripteurs français

KwdFr :
- Animaux (MeSH), Glutarédoxines (déficit), Glutarédoxines (génétique), Glutathion (métabolisme), Hyperréactivité bronchique (immunologie), Maladies pulmonaires (anatomopathologie), Mucus (MeSH), Métaplasie (anatomopathologie), Ovalbumine (immunologie), Pneumopathie infectieuse (étiologie), Poumon (anatomopathologie), Protéines (métabolisme), Souris (MeSH).
MESH :
- anatomopathologie : Maladies pulmonaires, Métaplasie, Poumon.
- déficit : Glutarédoxines.
- génétique : Glutarédoxines.
- immunologie : Hyperréactivité bronchique, Ovalbumine.
- métabolisme : Glutathion, Protéines.
- étiologie : Pneumopathie infectieuse.
- Animaux, Mucus, Souris.

English descriptors

KwdEn :
- Animals (MeSH), Bronchial Hyperreactivity (immunology), Glutaredoxins (deficiency), Glutaredoxins (genetics), Glutathione (metabolism), Lung (pathology), Lung Diseases (pathology), Metaplasia (pathology), Mice (MeSH), Mucus (MeSH), Ovalbumin (immunology), Pneumonia (etiology), Proteins (metabolism).
MESH :
- chemical , deficiency : Glutaredoxins.
- chemical , genetics : Glutaredoxins.
- etiology : Pneumonia.
- immunology : Bronchial Hyperreactivity, Ovalbumin.
- chemical , metabolism : Glutathione, Proteins.
- pathology : Lung, Lung Diseases, Metaplasia.
- Animals, Mice, Mucus.

Abstract

Protein-S-glutathionylation (PSSG) is an oxidative modification of reactive cysteines that has emerged as an important player in pathophysiological processes. Under physiological conditions, the thiol transferase, glutaredoxin-1 (Glrx1) catalyses deglutathionylation. Although we previously demonstrated that Glrx1 expression is increased in mice with allergic inflammation, the impact of Glrx1/PSSG in the development of allergic airways disease remains unknown. In the present study we examined the impact of genetic ablation of Glrx1 in the pathogenesis of allergic inflammation and airway hyperresponsiveness (AHR) in mice. Glrx1(-/-) or WT mice were subjected to the antigen, ovalbumin (OVA), and parameters of allergic airways disease were evaluated 48 h after three challenges, and 48 h or 7 days after six challenges with aerosolized antigen. Although no clear increases in PSSG were observed in WT mice in response to OVA, marked increases were detected in lung tissue of mice lacking Glrx1 48 h following six antigen challenges. Inflammation and expression of proinflammatory mediators were decreased in Glrx1(-/-) mice, dependent on the time of analysis. WT and Glrx1(-/-) mice demonstrated comparable increases in AHR 48 h after three or six challenges with OVA. However, 7 days postcessation of six challenges, parameters of AHR in Glrx1(-/-) mice were resolved to control levels, accompanied by marked decreases in mucus metaplasia and expression of Muc5AC and GOB5. These results demonstrate that the Glrx1/S-glutathionylation redox status in mice is a critical regulator of AHR, suggesting that avenues to increase S-glutathionylation of specific target proteins may be beneficial to attenuate AHR.

DOI: 10.1152/ajplung.00167.2012
PubMed: 22752969
PubMed Central: PMC3468477

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000826
to stream Main, to step Curation: 000826

Le document en format XML

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<term>Bronchial Hyperreactivity (immunology)</term>
<term>Glutaredoxins (deficiency)</term>
<term>Glutaredoxins (genetics)</term>
<term>Glutathione (metabolism)</term>
<term>Lung (pathology)</term>
<term>Lung Diseases (pathology)</term>
<term>Metaplasia (pathology)</term>
<term>Mice (MeSH)</term>
<term>Mucus (MeSH)</term>
<term>Ovalbumin (immunology)</term>
<term>Pneumonia (etiology)</term>
<term>Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Glutarédoxines (déficit)</term>
<term>Glutarédoxines (génétique)</term>
<term>Glutathion (métabolisme)</term>
<term>Hyperréactivité bronchique (immunologie)</term>
<term>Maladies pulmonaires (anatomopathologie)</term>
<term>Mucus (MeSH)</term>
<term>Métaplasie (anatomopathologie)</term>
<term>Ovalbumine (immunologie)</term>
<term>Pneumopathie infectieuse (étiologie)</term>
<term>Poumon (anatomopathologie)</term>
<term>Protéines (métabolisme)</term>
<term>Souris (MeSH)</term>
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<keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Glutaredoxins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glutaredoxins</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies pulmonaires</term>
<term>Métaplasie</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Glutarédoxines</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pneumonia</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glutarédoxines</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Hyperréactivité bronchique</term>
<term>Ovalbumine</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Bronchial Hyperreactivity</term>
<term>Ovalbumin</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glutathione</term>
<term>Proteins</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glutathion</term>
<term>Protéines</term>
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<term>Mice</term>
<term>Mucus</term>
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<term>Mucus</term>
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<front><div type="abstract" xml:lang="en">Protein-S-glutathionylation (PSSG) is an oxidative modification of reactive cysteines that has emerged as an important player in pathophysiological processes. Under physiological conditions, the thiol transferase, glutaredoxin-1 (Glrx1) catalyses deglutathionylation. Although we previously demonstrated that Glrx1 expression is increased in mice with allergic inflammation, the impact of Glrx1/PSSG in the development of allergic airways disease remains unknown. In the present study we examined the impact of genetic ablation of Glrx1 in the pathogenesis of allergic inflammation and airway hyperresponsiveness (AHR) in mice. Glrx1(-/-) or WT mice were subjected to the antigen, ovalbumin (OVA), and parameters of allergic airways disease were evaluated 48 h after three challenges, and 48 h or 7 days after six challenges with aerosolized antigen. Although no clear increases in PSSG were observed in WT mice in response to OVA, marked increases were detected in lung tissue of mice lacking Glrx1 48 h following six antigen challenges. Inflammation and expression of proinflammatory mediators were decreased in Glrx1(-/-) mice, dependent on the time of analysis. WT and Glrx1(-/-) mice demonstrated comparable increases in AHR 48 h after three or six challenges with OVA. However, 7 days postcessation of six challenges, parameters of AHR in Glrx1(-/-) mice were resolved to control levels, accompanied by marked decreases in mucus metaplasia and expression of Muc5AC and GOB5. These results demonstrate that the Glrx1/S-glutathionylation redox status in mice is a critical regulator of AHR, suggesting that avenues to increase S-glutathionylation of specific target proteins may be beneficial to attenuate AHR.</div>
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<ArticleTitle>Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease.</ArticleTitle>
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<Abstract><AbstractText>Protein-S-glutathionylation (PSSG) is an oxidative modification of reactive cysteines that has emerged as an important player in pathophysiological processes. Under physiological conditions, the thiol transferase, glutaredoxin-1 (Glrx1) catalyses deglutathionylation. Although we previously demonstrated that Glrx1 expression is increased in mice with allergic inflammation, the impact of Glrx1/PSSG in the development of allergic airways disease remains unknown. In the present study we examined the impact of genetic ablation of Glrx1 in the pathogenesis of allergic inflammation and airway hyperresponsiveness (AHR) in mice. Glrx1(-/-) or WT mice were subjected to the antigen, ovalbumin (OVA), and parameters of allergic airways disease were evaluated 48 h after three challenges, and 48 h or 7 days after six challenges with aerosolized antigen. Although no clear increases in PSSG were observed in WT mice in response to OVA, marked increases were detected in lung tissue of mice lacking Glrx1 48 h following six antigen challenges. Inflammation and expression of proinflammatory mediators were decreased in Glrx1(-/-) mice, dependent on the time of analysis. WT and Glrx1(-/-) mice demonstrated comparable increases in AHR 48 h after three or six challenges with OVA. However, 7 days postcessation of six challenges, parameters of AHR in Glrx1(-/-) mice were resolved to control levels, accompanied by marked decreases in mucus metaplasia and expression of Muc5AC and GOB5. These results demonstrate that the Glrx1/S-glutathionylation redox status in mice is a critical regulator of AHR, suggesting that avenues to increase S-glutathionylation of specific target proteins may be beneficial to attenuate AHR.</AbstractText>
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Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease.

Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease.

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